German researchers learn more about cancer pain
Researchers from the Pharmacology Institute of the University of Heidelberg in Germany have revealed possible answers as to why conventional medicine is often ineffective against severe cancer pain. They discovered that tumors release two signal substances that make nerve cells sensitive and enhance tumor growth. These molecules were formerly identified only as growth factors for blood-forming stem cells, but the new findings are consistent with cancer patient reports that simply touching an affected area is painful. Researchers also showed that tumor growth itself induces pain because the expanding tissue exerts pressure.
Animal studies found that blocking the effect of the signal substances with injected antibodies helped to reduce the sensitivity of nerve cells and tumor growth. If results can be duplicated in human tissue, these antibodies could be injected directly into tumors to reduce pain and side effects in cancer patients.
For the full story, go to Oncology Nursing News.
